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Lercanidipine [Inn]: Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Lercanidipine [Inn] - General Information

Lercanidipine [Inn] is a calcium channel blocker of the dihydropyridine class.
It is sold under various commercial names including Zanidip.

 

Pharmacology of Lercanidipine [Inn]

Lercanidipine [Inn], a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Lercanidipine [Inn] is similar to other peripheral vasodilators. Lercanidipine [Inn] inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

 

Additional information about Lercanidipine [Inn]

Lercanidipine [Inn] Indication: For the treatment of Hypertension and management of angina pectoris and Raynaud's syndrome Mechanism Of Action: By deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, Lercanidipine [Inn] inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Lercanidipine Synonyms: Not Available Drug Category: Antihypertensive Agents Drug Type: Small Molecule; Approved Other Brand Names containing Lercanidipine: Lercanidipine [Inn]; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Lercanidipine [Inn]: Not Available Chemical IUPAC Name: O3-[1-[3,3-di(phenyl)propyl-methylamino]-2-methylpropan-2-yl] O5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical Formula: C36H41N3O6 Lercanidipine on Wikipedia: https://en.wikipedia.org/wiki/Lercanidipine Organisms Affected: Humans and other mammals